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We have used primary rat liver and mouse mammary fibroblast cell cultures as sources of factor(s) that stimulate the proliferation of human, rat, and mouse tumor cells in vitro. Human colon, human lung, and rat sarcoma tumor cells were stimulated to grow and proliferate by fibroblast conditioned media (CM). Mouse mammary tumor cells were only stimulated by fibroblast CM that had been activated by gamma-interferon or indomethacin. Liver CM stimulated mouse mammary tumor cells but not human or rat tumor cells. Media conditioned by DMBA-induced rat mammary tumors stimulated only mouse mammary tumor cells. These results suggest that fibroblasts secrete specific factor(s) that regulate or regulate the proliferation of certain tumor cell types and that these factor(s) are species and tissue specific.Nosocomial bacterial infections in surgical patients.
Patients hospitalized for surgery are at high risk of acquiring nosocomial infections. Risk factors for nosocomial infection in surgical patients include age and underlying morbidity. Most nosocomial infections can be prevented through adherence to aseptic technique and the use of prophylactic antibiotics. Postoperative infections are usually uncomplicated and related to the site of the operation, such as wound infections after herniorrhaphy and surgical site infections after laparotomy, and are usually treated with intravenous antibiotics and wound debridement. Important care practices that reduce the risk of postoperative infection include selective bowel decontamination, antibiotic prophylaxis, and proper hand hygiene.A Florida man was captured on surveillance video last week smashing the glass top off a display at a Wal-Mart that he thought was a gun.
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He was shopping with a friend at the Target store located inside the Tampa, Florida, Walmart.
After getting into an argument with another customer over an item
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The aim of this study is to analyze the effects of glucocorticoids in men with isolated hypogonadotropic hypogonadism and infertility. Twenty-three adult men were included. At baseline and 12 months later, their gonadotropin and sex steroid levels were measured. One patient was excluded due to treatment with the aromatase inhibitor letrozole. Testicular volume was assessed at baseline and at the end of the treatment period. At baseline, patients had low serum levels of testosterone, high levels of LH and FSH, high total plasma and free testosterone/SHBG ratios, and low levels of inhibin B, which were normalized by treatment with hydrocortisone. Ejaculated semen samples were abnormal in seven patients. After 12 months of treatment with hydrocortisone, gonadotropin and sex steroid levels and testicular volume had increased. Mean levels of plasma inhibin B and the percentage of sperm with normal morphology increased. Patients had become able to ejaculate and were no longer infertile. This is the first report to show that an increase in plasma inhibin B levels and in the percentage of morphologically normal sperm in patients with isolated hypogonadotropic hypogonadism correlate with the improvement in testicular size and potency after glucocorticoid treatment., «tcp6», «tcp6:dhcp», «», «», «», «», «»)
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